From synthesis to bench
Three documented stages.
Each stage exists to remove a specific way a reference material can be wrong: the wrong sequence, the right sequence at the wrong purity, or the right material degraded before it reached your bench.
01 — Synthesized
Peptides are produced by solid-phase peptide synthesis using Fmoc chemistry. The chain is assembled C-terminus first on a polymer resin, one residue at a time: the N-terminal Fmoc protecting group is removed, the next activated amino acid is coupled, and unreacted chains are capped so that a failed coupling terminates a chain rather than producing a deletion sequence that would be nearly impossible to separate later.
When the sequence is complete, the peptide is cleaved from the resin and its side-chain protecting groups are removed in a single acidic step, typically trifluoroacetic acid with scavengers appropriate to the residues present. Crude peptide is precipitated in cold ether, then purified by preparative reverse-phase HPLC — the same separation used analytically for release testing, run at scale, collecting only the fractions that meet the purity specification.
02 — Verified
Purified material is characterized before it is released: reverse-phase HPLC for purity, LC-MS for identity, and the LAL assay for bacterial endotoxin. Testing is contracted to an independent laboratory rather than performed alongside production, and the results are recorded against the lot number, which is what turns a claim into a record.
A lot that misses its specification is not released, and it is not blended into a conforming lot. The full methodology, and what each assay does and does not establish, is on the testing page.
03 — Delivered
Purified peptide is lyophilized — frozen and dried under vacuum by sublimation — which removes water without the heat that would degrade the material, and leaves a solid far more stable to hold than a solution would be. It is formulated and filled to the strength on the label; bottles are filled, sealed, and protected from light.
Temperature-sensitive items ship cold-chain, packed with coolant sized to the transit time rather than to the box. Every shipment leaves with the certificate of analysis for the lot it contains, so the documentation and the material never travel separately. Orders move via our shipping carriers with tracking supplied by email; full detail is on the shipping page.
What arrives
A sealed bottle, labelled with the compound, its strength, and the lot number that resolves to the certificate in the box — and the research-use-only statement that governs what the material may be used for. If any of those three do not match each other, the shipment is wrong and we want to hear about it.